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Taken together, these data suggest that the primary function of FTMT may be regulatory and protective, rather than a constant buffer of mitochondrial iron pools 42,43

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doi: 10.3389/fendo.2021.645194 142 HashemiPPezeshkiS

Developing agents targeting context-specific chain configurations, particularly PROTACs exploiting newly identified E3 ligase interfaces, could transform ubiquitin adaptability from a resistance mechanism into an actionable therapeutic vulnerability