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This adaptability enables macrophage polarization, which is the process by which macrophages mount a specific phenotypic and functional response to the microenvironmental stimuli encountered in a specific tissue (Sica and Mantovani, 2012)

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In addition, IL-4-treated BMDMs showed increased FAO dependency and capacity, but not FAO flexibility, compared with the control cells (Fig

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24:48824891 De Castilla PEM, Tong L, Huang C, Sofias AM, Pastorin G, Chen X, Storm G, Schiffelers RM, Wang J-W

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[DOI] [PMC free article] [PubMed] [Google Scholar] 443

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Thus, designing an all-rounder with space-time ROS scavenging, modulation of macrophage polarization, and promotion of angiogenesis and cell proliferation is a prominent subject for advancing the clinical treatment of chronic diabetic wounds

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