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Another candidate, ASO#27_C, showed the most potent heart Pln reductions but also evoked non-significant elevations in plasma ALT and AST (Fig

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Moreover, iron-sulfur cluster proteins, essential cofactors for maintaining redox balance and iron levels, are produced as auxiliary enzymes in cuproptosis, with their levels significantly decreasing following cuproptosis initiation

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Each concentration of 100 L was added to the 96-well plates, which were then incubated at 37 C in a humidified 5% CO 2 incubator