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In those with MTHFR gene variants, folate and folic acid metabolism is inhibited in such that the vitamin is not efficiently reduced to its active form, 5-methyl-tetrahydrofolate (5-MTHF)

doi: 10.1161/CIRCRESAHA.117.311401

Perales-Clemente, E., Folmes, C

(Investigator) 9/04/26 9/06/27 Project: Research Anderson, I

For the Clinician: The Deeper Approach Functional medicine moves past symptom suppression into systems biology , where CKD is seen as the downstream expression of multi-organ dysfunction