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The more active the immune system is the more NAD+ the enzyme consumes

they are also similar to those of Lottenberg et al

We do not know what happens at year two, or year five

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This relationship is thought to arise either from intrinsic immune dysregulationleading to impaired mucosal defense and tolerance breakdownor from extrinsic factors such as medications or infections that trigger or exacerbate autoimmunity (354)