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GPX4 plays a pivotal role in regulating lipid peroxides within cells and the reduction in GSH and GPX4 that we demonstrate in the IB3-1 AECs following FAC and erastin treatment is likely responsible for the increased lipid peroxidation that we found, as evidenced by the increase in MDA and C11-BODIPY

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Livingston MJ, Wang J, Zhou J, Wu G, Ganley IG, Hill JA, et al

Together, these signaling systems provide a framework for investigating how angiogenic signaling, cytoskeletal organization, and fibroblast-mediated extracellular matrix processes interact in laboratory models of tendon, ligament, and musculoskeletal tissue biology