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BPC-157 is currently undergoing clinical trials as a medication used to treat inflammatory bowel disease such as Crohn's disease and ulcerative colitis

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Interestingly, the deletion of Slc7a11 (which encodes xCT) in animals results in viable offspring 26 , suggesting that tissues (and potentially tumors) can obtain cysteine from another source

Together, these results mean that the metabolites of gut microbiota disturb regulation of joint FTN and homeostasis of iron, thereby may inducing iron overload that triggers ferroptosis and accelerate the development of OA

Disruption of methylation was suggested by several lines of evidence

doi: 10.1182/blood-2012-11-427765 70 ZhangDLGhoshMCRouaultTA