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NNMT inhibitors display high membrane permeability Compounds spanning ~100-fold IC 50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold[17] to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies

Graphical abstract Access this article Similar content being viewed by others References Shang L, Xu J, Nienhaus GU (2019) Recent advances in synthesizing metal nanocluster-based nanocomposites for application in sensing, imaging and catalysis

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