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These peptides have multiple antitumour, antioxidant, and immunomodulatory effects [46]

Ammonia treatment in vitro strongly inhibited the release of newly loaded radiolabeled glutamine from cultured astrocytes (Dbrowska et al., 2018) and the inhibition involved changes in protein kinase C signaling (Dbrowska et al., 2018), Sp1-Nrf2 transcription factor complex formation (Dbrowska and Zieliska, 2019), and activation of Nrf2 transcription factor per se (Dbrowska et al., 2021)

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Additionally, the use of disulfide bonds as linkers is favored because they are highly stable during blood circulation and will only break down when entering the tumor environment, thereby facilitating targeted delivery of chemotherapeutics to the tumor site alone and minimizing unwanted side effects [57]