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10.1186/s12906-022-03538-9 244 WangD

This is seen with -synuclein in Parkinson disease (PD) 32 , tau in various dementias 33 and mutant huntingtin in Huntington disease (HD) 31

Nevertheless, double heterozygote MTHFR 677 C/T and 1298 A/C results in the lowest MTHFR activity

Where microtubules are destroyed, and tau oligomers (tauO) are pathological, p53 cannot enter the nucleus

Zhang J, Chen B, Li H et al (2023) Cancer-associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2-IGF1R and Hippo-YAP1 signaling pathways