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Neddens J, Temmel M, Flunkert S, Kerschbaumer B, Hoeller C, Loeffler T, Niederkofler V, Daum G, Attems J, Hutter-Paier B

161 Although many traditional formulations are supported by in vitro and in vivo studies, 162 the precise pharmacological effects of individual herbs on inner ear physiology are often incompletely characterized

These modifications are seen as DNA damage as a response to methylglyoxal stress, however, the subsequent effects are currently unclear [22]

Furthermore, a reduction in ATP production from the electron transport chain increases the reliance on glycolysis, resulting in the inhibition of the tricarboxylic acid cycle, accumulation of lactate, and decrease in intracellular pH

10.1038/s41586-018-0519-y 339 SeverR.BruggeJ