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The researchers noted a clear dose-response relationship, where higher doses yielded better clinical outcomes, particularly in patients who carried variations in the MTHFR gene

This is when they release pro-inflammatory signals that can actually hinder long-term healing

Flores-Mrquez EL, Suriach E, Galindo-Zaldvar J, Maldonado A (2003) Three-dimensional gravity inversion model of the deep crustal structure of the central Drake Passage (Shackleton Fracture Zone and West Scotia Ridge, Antarctica)