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With aging, accumulated oxidative damage leads to a decline in granulosa cell autophagy

Other important parameters are the polar surface area and the number of hydrogen (H) bonds of the molecules

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Kilberg MS, Handlogten ME, Christensen HN: Characteristics of system ASC for transport of neutral amino acids in the isolated rat hepatocyte

IGF-1 can act over its putative receptor (IGF-1R) or it can also bind to the insulin receptor (IR), albeit with less affinity [98100]