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Description

Comparative evaluation of the hepatoprotective, antioxidant and choleretic activity of flavonoid drugs

Excessive ROS can boost the expression of pro-inflammatory cytokines including IL-1, TNF-, IL-6, and COX-2 to regulate the inflammatory response [216, 217], as well as make the MMPs/TIMPs ratio imbalanced by activating MMPs and decreasing TIMP production, decompressing ECM [218]

PMID: 15687241

10.18087/cardio.2022.6.n165235834345 294 Zhang EY, Kou L, Li M, et al

Despite the lack of consistent study design, the authors concluded that there is little or no evidence to support the hypothesis that proinflammatory circulating cytokines are raised in CFS (104)