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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

Some research suggests that low vitamin B12 combined with high folic acid intake may be associated with elevated homocysteine and methylmalonic acid levels

The loss of pericytes around ECs is common in DR and is attributed to the damaging effects of CH.Citation 38 It is believed that the angiopoietin-TIE2 system is largely responsible for the normal interaction between ECs and pericytes to stabilize vasculature

Nakamura, E

Arsenault, Benoit J., et al

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