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Animal studies spanning over a decade confirm significant improvements in esophagitis, sphincter function, and overall digestive health with both injectable and oral administration

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By interacting with amylin and calcitonin receptor-related pathways, the peptide has become an important focus of metabolic research and clinical development

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Treatments are vehicle (V), CagriSema (CS, 2 + 2 nmol/kg), and calorie-restricted to match the weight of the CS rats (weight matched, WM)

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