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In addition, the activity and expression of SLC7A11 is strictly regulated by multiple mechanisms, such as transcription factor 4 (ATF4), nuclear factor erythroid 2related factor 2 (NRF2), ubiquitin BRCA1 (Breast cancer gene 1)-associated protein-1 (BAP1), the SWI/SNF complex, and rapamycin complex 1 (mTORC1) (51), through which the expression of SLC7A11 can be upregulated to enhance the antioxidant defense of cells and inhibit the occurrence of ferroptosis ( Figure 1B )

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The resultant mixture was stirred magnetically at 65C on a hotplate magnetic stirrer (MS-H550-Pro, Medfuture Biotech Co., Jinan, China) for 1 hour, ensuring complete ethanol evaporation, leading to niosome formation

The increased ConA-stimulated proliferation of PBMC due to LPS injection is a good indicator of a functioning immune response and indicates that e