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E-mail: [email protected] Received: 06 March 2020 / Accepted: 09 March 2020 DOI: 10.31491/APT.2020.03.014 Abstract GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide found in human serum with levels averaging 200 ng/ml at age 20 but declining to an average of 80 ng/ml by age 60

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Anal Biochem 86:271278 Mohammadnejad D, Abedelahi A, Mohammadi-roshandeh A, Azami A (2012) Degenerative effect of cisplatin on testicular germinal epithelium

In PTZs, substitutions at the C-10 position, such as alkyl or aryl groups, reduce activity, whereas modifications at the C-2 position significantly enhance potency, such as featuring a 2-phenyl-methyl piperazine at C-2, which demonstrated remarkable activity with an EC50 of 0.5 nM in erastin-induced ferroptosis in HT-1080 cells (Yang et al., 2021)

Notably, they were localised to the same zone as the TUNEL positive cells and contained one or more DAPI positive nuclei in their processes which were clearly separate from the nucleus of the host cell demonstrating engagement in the uptake of neighbouring apoptotic cells

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