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SinghAVChandrasekarVJanapareddyPMathewsDELauxPLuchAet al

and EL-HACK, M.E.A

Rall and Lehninger 5 calculated that the E m 7 GSH cannot be more negative than 0.13 V (with the new value of E m 7 NADPH 2 (ref

doi: 10.1056/NEJMoa043331 4 LimaFRKahnSASolettiRCBiasoliDAlvesTda FonsecaACet al

Cellular GSH level is maintained by a complex homeostatic mechanism, among which glutamate cysteine ligase (GCL), consisting of catalytic (GCLC) and regulatory (GCLM) subunits, plays major roles in GSH synthesis