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Kidney and cardiovascular outcomes SURPASS-4 kidney composite HR 0.58, slower eGFR decline (-1.4 vs -3.6 mL/min/1.73m2/yr), UACR -6.8% vs +36.9%

The major bottlenecks for this therapy include ensuring long-term survival, functional integration of transplanted mitochondria into host cells, and development of standardized, scalable protocols for mitochondrial isolation and delivery