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The underlying pathogenic cause of peripheral neuropathy in these individuals is reduced pyruvate flux due to hyperphosphorylation of pyruvate dehydrogenase complex (36

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The authors sincerely thank all the children and their parents for their participation in this study

Furthermore, quercetin disrupts DNA repair mechanisms, including homologous recombination and non-homologous end-joining, which contributes to mitotic catastrophe in NSCLC cells [200]

While side effects are rare, some individuals may experience mild discomfort at the injection site or temporary symptoms such as dizziness or nausea

doi: 10.1167/iovs.16-20600 33 GiebelSJMenicucciGMcGuirePGDasA