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The rationale is that piplartine prevents kanamycin from entering mouse ear tissue by increasing the expression of TRPV1, thereby preventing kanamycin-induced hair cell loss and protecting the hearing of mice (Zallocchi et al., 2024)

One exceptional example is that the application of pharmacological intervention with the SLC1A5 inhibitor V9302 demonstrated remarkable selectivity in blocking glutamine uptake specifically in TNBC cells, while leaving CD8 + T cells unaffected [134]