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In rat model of arthritis, P-Dex had better and longer-acting anti-inflammatory effects than free Dex when given systemic

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited published safety data Reported well-tolerated in small Russian studies Known interactions GABAergic medications (theoretical unstudied) Benzodiazepines (theoretical additive sedation) Contraindications Pregnancy/lactation (unstudied) Hypersensitivity REGULATORY STATUS FDA Not FDA-approved

Notably, there was no consistent pattern of DILI linked to the progression toward chronicity, making long-term outcomes unpredictable in these patients [78]

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