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the combined therapy of 2.5 mg/kg leflunomide and HBOT yielded significant improvements in foot edema and arthritis scores, compared to HBOT monotherapy

For ESI+, the mass spectrometer settings were as follows: capillary voltage of 4500 V, nebulizer gas pressure of 2.0 bar, dry gas flow rate of 10 L min -1 , dry gas temperature of 220C, mass scan range of 50-1300 m/z, spectra acquisition rate of 10 Hz, and cycle time of 0.4 s

Additionally, an imbalance in intestinal flora also interferes with the metabolism of key nutrients, such as proteins, lipids, and carbohydrates, thereby influencing kidney health [91, 92]

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Key Terms buoyant force : An upward force exerted by a fluid that opposes the weight of an immersed object