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These metabolic shifts increase energy expenditure, suppress lipogenesis, and rejuvenate muscle stem cell function, providing a unique mechanism for combating obesity, fatty liver, and age-related muscle decline 1-3

Angeli et al., 2015b)

It seems that the acidic environment in tumors is associated with the more aggressive tumor characteristics such as metastasis, angiogenesis, and therapy resistance (Estrella et al., 2013