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4,5 Without adequate disease control, UC may result in gastrointestinal symptoms such as bloody diarrhoea, faecal urgency, incontinence, abdominal pain, fatigue, weight loss and nutritional deficiencies, together with extraintestinal manifestations that include arthritis, skin disease and iritis

This led to a focused research program that ultimately produced PT-141

This crosstalk implies that cytokine-driven upregulation of FABP5 amplifies oxidative stress, which in turn fuels cytokine release from dying keratinocytes (Fig

Biomed Res Ther 5(11):28112819 Krhenbhl S, Hasler F, Krapf R (1994) Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals

Unfortunately, the diagnosis of the affected dog in the occult (asymptomatic) stage is much more difficult and will be discussed below

Moreover, the strong sensitivity of LMs to external conditions, such as viscosity changes caused by temperature fluctuations or interactions with surrounding media, further reduces control reliability