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Tamoxifen and trametinib have been shown to inhibit BIPN by antagonizing the PKC and ERK, respectively (Tsubaki et al., 2018a

In pediatric populations, congenital hypothyroidism and untreated iodine deficiency remain major causes of intellectual disability worldwide (81)

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J Neuroinflammation 6:9 Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin