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The synthetic lethal relationship between ACS1 and ACL1 was expected to sensitize the acl1 mutant to Cn Acs1 inhibitors

The control group received an intraperitoneal injection of physiological buffer saline (PBS)

Integrated multi-omic platforms that combine genomics, transcriptomics, proteomics, and metabolomics have enabled deep dissection of IBD pathogenesis and its inherent heterogeneity