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Procyanidin oligomers and polymers reach the large intestine where they are subjected to microbial metabolism yielding e.g., phenylvalerolactones (see section 6.1 Pre-systemic metabolism: role of gut microbiota)

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Fenton OS, Kauffman KJ, Kaczmarek JC, McClellan RL, Jhunjhunwala S, Tibbitt MW, Zeng MD, Appel EA, Dorkin JR, Mir FF, Yang JH, Oberli MA, Heartlein MW, DeRosa F, Langer R, Anderson DG