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Whereas preclinical and clinical research have extensively expounded on these target organ interventions, clinical application and instance-based evidence on clinical translatability are needed

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459,460 At the early stage of myocardial infarction, glycolysis of macrophages is upregulated and macrophages are mainly in the M1 phenotype, while at the late stage, glycolysis decreases to basal levels, and macrophages are mainly in the M2 phenotype