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Those with High-Stress Lifestyles: Stress can deplete B12 levels, so individuals leading hectic lives may notice significant benefits from supplementation

In contrast, synthetic, proliferative VSMCswhich dominate pathologies such as atherosclerosisundergo a metabolic shift toward glycolysis and possess reduced antioxidant defenses, rendering them highly vulnerable to cuproptosis [154, 155]

10.18632/oncotarget.6133 29 KangY

[DOI] [PMC free article] [PubMed] [Google Scholar] 161.George S, et al

This article presents the 5-year longitudinal data in the FA-COMS study, a large international collaborative study on the natural history of Friedreich ataxia

But it must be acknowledged that, like heavy metals, excessive concentrations of metal ions from the aforementioned metals can induce various forms of cellular damage and apoptosis, resulting in increased wound inflammation and oxidative stress responses (Song et al., 2019)