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Secondly, Verapamil modulates host immune responses by promoting macrophage activation and increasing the production of reactive oxygen species (ROS) and nitric oxide (NO), which contribute to the killing of intracellular mycobacteria [83]

These downstream structural changes persist substantially longer than plasma detection of the parent compound

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Studies have reported OCTN2 expression in respiratory epithelial cells and alveolar macrophages, which is especially high in the upper lung region [301], and OCTN2-mediated carnitine uptake plays an important role in maintaining respiratory cilia beating and airway mucociliary clearance function, helping to remove excess mucus and potentially harmful substances from the airway [302]

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