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Accurate differentiation between NAFLD subtypesincluding NAFL, NASH, and fibrosiscontinues to rely heavily on histopathological analysis, constraining epidemiological stratification and longitudinal assessments [103, 104]

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The copper- and zinc-containing cytosolic SOD (Cu/Zn SOD, SOD1) is a 32 kDa homodimer abundantly expressed in astrocytes and present in plasma, lymph, and cerebrospinal fluids [14]