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Cagrilintide targets multiple mechanisms to reduce appetite and body weight: Delays gastric emptying Promotes satiety via the brains hypothalamus Reduces food cravings and portion size Suppresses glucagon secretion Improves metabolic flexibility Cagrilintides effect is particularly powerful when combined with GLP-1 agonists or lifestyle changes such as reduced-calorie diets, regular exercise, and sleep optimization

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In psychiatric disorders, abnormalities of melatonin secretion and regulation have been reported [7, 8]

Animals were included in experiments at 8 weeks of age with randomization into different experimental groups without blinding