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Tissue PO 2 decreases gradually into the renal medulla, reaching 1015 mmHg in the renal inner medulla 19

J Med Virology 1997;52:301-308

The release of cytochrome c into the cytoplasm triggers the activation of initiator caspase 9 (CASP9), followed by the sequential activation of caspase 3 (CASP3) and caspase-7 (CASP7), known as executioner caspases (Fig