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Unlike the WT-Bcr-Abl mice, the survival of T315I leukemia mice was not significantly prolonged by JMF4073 (Fig

glyoxalases, which use GSH to detoxify reactive dicarbonyl species including methylglyoxal and glyoxal

To minimize adverse effects, taking a secondary medication with a complementary mode of action is advisable before taking the initial drug at the maximum recommended dose (143)