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Proton magnetic resonance spectroscopy ( 1 H MRS), with its extremely high sensitivity, is used for detecting and quantifying several endogenous tissue metabolites in a single acquisition, but it is not capable of tracking the activity of a metabolic pathway due to limitations related to water, lipid suppression, and magnetic field homogeneity [22]

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In PTMA, impaired erythropoiesis leads to intramedullary destruction of nucleated RBCs, presenting with markedly elevated LDH and borderline haptoglobin levels, which are not typically expected with intravascular hemolysis in TMA

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10.1186/s12967-023-04120-8 40 LiuL.ZhaoM.LangX.JiaS.KangX.LiuY.et al (2024)