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Phase I reactions include hydrolysis, reduction, hydroxylation, and oxidation, which results in water-soluble metabolites and further facilitate their excretion and conjugation

Chest 119:394401

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2021;4:e2120040

Taken together, these studies profoundly challenge the concept of oxidative stress as the mere or prime cellular mediator of intracellular copper action, but rather highlight much subtler actions of this transition metal