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The similarities in the dendritic responses to the AngIV analogues and HGF are consistent with a common mechanism of action

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Regulation of CD4 + T cell lineage commitment and function by lipid metabolism Fatty acids and CD4 + T cell differentiation Accumulating evidence suggests that how T cells acquire metabolites plays a pivotal role in determining cell differentiation outcomes, in addition to the impact of the metabolites themselves

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observed in Nature Medicine , NNMT inhibition in adipose tissue produced favorable body composition changes without negatively impacting muscle mass (Kraus et al., Nature Medicine )