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Treatment of human colon cancer RKO cells with SGI-1027 led to the re-expression of silenced TSG and the degradation of DNMT1

JCI Insight 1:e89073

Acknowledgements We acknowledge Ms Janadaree Bandara, Universirty of Peradeniya, for providing the insecticide-impregnated papers for the bioassay tests, Dr Thilini Weeraratne and Ms Sumudu Samarasinghe for assistance with molecular analysis, Mr M

doi: 10.18632/aging.203131 129 TangLXiaoQMeiYHeSZhangZWangRet al

1995;126(5 Pt 1):6905

Elevated levels of O 2 , H 2 O 2 , OH , nitric oxide (NO), and glutathione disulfide (GSSG), peroxides, depletion of GSH, and oxidation of methionine and cysteine moieties in cataractous lenses, all indicate the involvement of ROS and RNS in cataract formation [5965]