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Second, in latently infected macrophages the metabolic steps in the tricarboxylic acid (TCA) cycle preceding oxidative phosphorylation (OXPHOS) were compromised, resulting in lipid accumulation, which is typically observed in several tissues and cells in the HIV infected population 18,19

NFE2L2, also known as NRF2, is a transcription factor involved in cellular response to oxidative stress

AATF protein contains three serine/threonine-glutamine (S/T-Q) motifs at its residues Ser189, Thr394, and Thr410, which are the potential phosphorylation sites for kinases involved in activating DNA damage responses, including ATM, ATR, and DNA-PKcs 32,33

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Good practices include detox support, hydration, gut health, and focus on keeping down inflammation

Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products