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for many of these, neither disease-preventing nor disease-modifying medicines exist

This was best summed up in a BMJ editorial last year, which noted that diagnosing B12 deficiency can be "challenging" because no "single specific measurement exists to reliably diagnose or refute the presence of B12 deficiency"

For example, intraperitoneally administered N-acetylcysteine was shown to increase hepatic and intestinal glutathione levels in bile-duct ligated rats[25]

In Pseudomonas aeruginosa , positive selection for promotor mutations that increase expression of the bacterial uptake system phu (pyoverdine siderophore) occurs exclusively among isolates from patients with cystic fibrosis that show enhanced bacterial growth (Marvig et al., 2014)

Highlighted studies include those of Lpez-Cacho et al