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Description

This may indicate that this enzyme is not the molecular target of auranofin in T

The function of these two antifolates is to disorder the cell replication and division cycles in microbes by interfering DNA biosynthesis [17, 23, 35, 56]

Nat Rev Endocrinol

Nature 443 , 787795 (2006)

30 CavadiniP.ONeillH

This could be due to the remarkable difference in the cell size of the two species (2.2-3.0 x 3.0-5.2m S.bacillaris ( S.cerevisiae ( GSH is synthesised starting from glutamate and cysteine to form -glutamylcysteine (-GluCys), which is subsequently conjugated to glycine