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Gasdermin D (GSDMD) is a central protein controlling pyroptosis

Pinnaratip, R., Bhuiyan, M

Future progress will depend on harmonizing formulations, refining targeted delivery, and validating outcomes in robust clinical settings

Nature 508 , 483487 (2014)

Since the type of ROS mediating the intracellular apoptosis signal has not been identified, investigating the role of GPx1 in the apoptosis pathway may provide insight into H 2 O 2 signals that serve as apoptotic messengers