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No adequately powered randomized trial has taken healthy people, genotyped them at these loci, assigned them to different B12 forms, and shown a genotype-by-form interaction on a hard functional outcome

Overcoming HLA restriction in clinical trials: immune monitoring of mRNA-loaded DC therapy

Methylcobalamin: Which Form

While certain peptides (such as semaglutide) are FDA-approved for specific medical indications, others may be used off-label based on individualized patient needs

Deficiency is also particularly common in elderly people, as the ability to absorb B12 decreases with age

The fact that the OLV group also had elevated levels of methylmalonic acid indicates, once again, that they are also at potential risk, and that many of them do not supplement and/or believe they meet their requirements from food