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These mechanisms do not operate in isolation but rather form a self-amplifying vicious cycle: mitochondrial damage exacerbates OS and promotes pathological -syn aggregation

Zhao J, Chen AX, Gartrell RD, Silverman AM, Aparicio L, Chu T, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Schmidt M.E., Liebowitz M.R., Stein M.B., Grunfeld J., Van Hove I., Simmons W.K., Van Der Ark P., Palmer J.A., Saad Z.S., Pemberton D.J., et al

In contrast, high oral doses of free lipoic acid (50 mg) significantly, yet transiently, increase the concentration of free lipoic acid in plasma and cells