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Statistical analyses were performed using IBM SPSS software, with significance set at p 0.05)

Without it, mice had normal blood vessel formation in fat tissue but reduced fatty acid uptake, resulting in smaller fat depots

Monson EA, Crosse KM, Das M, Helbig KJ (2018) Lipid droplet density alters the early innate immune response to viral infection

Du S, Guan Y, Xie A, et al

SirT3 is a nuclear NAD + -dependent histone deacetylase that translocates to the mitochondria upon cellular stress

Validating urine-based biomarkers (e.g., exosomal ferroptosis-related proteins and 4-HNE metabolites) or circulating ferroptosis signatures that predict CIN risk, severity, or response to interventions is urgently needed to guide clinical decision-making