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Oxidative stress, a hallmark of acute TBI, represents another potent biochemical trigger for astrocyte activation

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Lipid peroxidation-derived aldehydes in OA As the most abundant and toxic lipid peroxidation-derived aldehyde, 4-HNE has been shown to be involved in the development of many disorders such as cardiovascular diseases [57], neurological diseases [58], inflammatory bowel disease [59], diabetes [60], RA [61], and different types of cancer [62,63,64]

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it needs steady daily intake to keep reserves topped up

Predictors of clonal evolution in metastatic colorectal cancer patients