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Specifically, IGF-I can increase the number of CD4 + CD8 + immature T cells in rat thymus and spleen[162], promotes T cell survival[163], proliferation, chemotaxis and maturation, and blocks spontaneous and induced programmed cell death[163, 164], although it has also been reported to block IL-2-dependent lymphocyte growth and function[165]

Because of the evolving pathophysiologic pathways mechanisms and the diversity of causes and risk factors, preventive interventions are desperately needed to lower the prevalence of PIPN [16]

Serum was concentrated using a qEV concentration and isolation kit, followed by extraction of exosomal RNA for small RNA sequencing via next-generation sequencing (NGS)

DUTCH is a group of validated tests that provide a complete evaluation of sex and adrenal hormones, including metabolites

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