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Most small molecule binders of the oxytocinase subfamily of M1 aminopeptidases, e.g., the phosphinic pseudotripeptides 4346 address the active site and establish strong interactions with the catalytic zinc ion

While gene therapy is available for a small subset of patients with specific mutations, developing a therapeutic that broadly targets the cellular stresses that lead to cell death could address a major unmet need

Woods KA, van Helvoirt M, Ong KK, Mohn A, Levy J, de Zegher F, Dunger DB: The somatotropic axis in short children born small for gestational age: relation to insulin resistance

Fukutin is a glycosyltransferase that transfers ribitol 5-phosphate from cytidine diphosphate-ribitol to the sugar chains of -dystroglycan 8 , which is necessary for linking basal lamina with the cytoskeletal proteins in skeletal muscle and brain

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181 demonstrated in a nematode model that Lycii Fructus (Gouqizi) upregulates SOD and CAT expression while reducing lipofuscin accumulation, with its antioxidant effects strongly correlating with lifespan extension